Dangerous Drugs

While overdose deaths from prescription opioids have nearly quadrupled since 1999, some of the most dangerous drugs don’t require a prescription.

Using data from the Food and Drug Administration for 2004 through 2015, HealthGrove looked at the 150 drugs that are involved in the highest number of adverse reactions and ranked them by the percent of these reactions classified as serious. For many of these reactions, the FDA database uses medical terminology, such as pyrexia and dyspnoea for fever and labored breathing, respectively.

The top 50 drugs with the most serious adverse reactions are considered the most dangerous. Though most on the list require a prescription and treat serious diseases, those like Advil and acetaminophen don’t.

It’s important to note that these medicines may not be inherently dangerous, but improper dosage, combining medicines or taking them with substances like alcohol can dramatically increase risk.

One-third of Americans say they “combine medications when treating multiple symptoms,” according to the National Council on Patient Information, cited in a New York Times report on over-the-counter medicines. The same source also claims that only one in ten people read the labels entirely and one in five admits to using medication more than the label indicates. This creates an environment primed for unintended drug interactions and overdoses.

Additionally, people over 65 years old — those most likely to take multiple drugs for chronic health issues — account for approximately 40 percent of over-the-counter drug usage. This puts this group at greater risk for trouble with these drugs by way of adverse side effects and interactions.

Despite the potential for negative consequences of drug use and misuse, modern pharmaceuticals have greatly contributed to the health and longevity of people around the world. Though many are regarded as safe, as more drugs become available over the counter and prescriptions of others rise, consumer awareness becomes increasingly important.

Note: In the case of ties, the drug with the highest number of total reported reactions is ranked higher.

50Losartan

[graphiq id=”jjpj2YRtXX7″ title=”Common Adverse Reactions Associated With Losartan” width=”600″ height=”569″ url=”https://w.graphiq.com/w/jjpj2YRtXX7″ link=”http://drugs.healthgrove.com/l/1805/Losartan” link_text=”Common Adverse Reactions Associated With Losartan | HealthGrove” ]

Percent of Reactions That Were Serious: 70%
Number of Serious Reactions: 24,242
Total Number of Reported Reactions: 34,571
Therapeutic Class: Cardiovascular Agent
Brand Names: Cozaar

49Alprazolam

[graphiq id=”j7grcuvehDL” title=”Common Adverse Reactions Associated With Alprazolam” width=”600″ height=”569″ url=”https://w.graphiq.com/w/j7grcuvehDL” link=”http://drugs.healthgrove.com/l/4874/Xanax” link_text=”Common Adverse Reactions Associated With Alprazolam | HealthGrove” ]

Percent of Reactions That Were Serious: 70%
Number of Serious Reactions: 51,950
Total Number of Reported Reactions: 73,606
Therapeutic Class: Antianxiety
Brand Names: Gabazolamine-0.5, Niravam, Xanax, Xanax Xr, Alti-Alprazolam

48Tramadol

[graphiq id=”k98JsI7iDM9″ title=”Common Adverse Reactions Associated With Tramadol” width=”600″ height=”569″ url=”https://w.graphiq.com/w/k98JsI7iDM9″ link=”http://drugs.healthgrove.com/l/2044/Tramadol” link_text=”Common Adverse Reactions Associated With Tramadol | HealthGrove” ]

Percent of Reactions That Were Serious: 71%
Number of Serious Reactions: 26,278
Total Number of Reported Reactions: 36,867
Therapeutic Class: Analgesic
Brand Names: Conzip, Fusepaq Synapryn, Rybix Odt, Ryzolt, Ultram, Ultram Er

47Venlafaxine

[graphiq id=”cqC2CI0uoUB” title=”Common Adverse Reactions Associated With Venlafaxine” width=”600″ height=”571″ url=”https://w.graphiq.com/w/cqC2CI0uoUB” link=”http://drugs.healthgrove.com/l/1817/Venlafaxine” link_text=”Common Adverse Reactions Associated With Venlafaxine | HealthGrove” ]

Percent of Reactions That Were Serious: 71%
Number of Serious Reactions: 33,623
Total Number of Reported Reactions: 47,132
Therapeutic Class: Antidepressant
Brand Names: Effexor, Effexor-Xr

46Sertraline

[graphiq id=”dNMqYkPfxL7″ title=”Common Adverse Reactions Associated With Sertraline” width=”600″ height=”571″ url=”https://w.graphiq.com/w/dNMqYkPfxL7″ link=”http://drugs.healthgrove.com/l/1386/Zoloft” link_text=”Common Adverse Reactions Associated With Sertraline | HealthGrove” ]

Percent of Reactions That Were Serious: 71%
Number of Serious Reactions: 45,622
Total Number of Reported Reactions: 64,182
Therapeutic Class: Antidepressant
Brand Names: Zoloft

45Metoprolol

[graphiq id=”heHpQoS9oSp” title=”Common Adverse Reactions Associated With Metoprolol” width=”600″ height=”571″ url=”https://w.graphiq.com/w/heHpQoS9oSp” link=”http://drugs.healthgrove.com/l/3072/Metoprolol” link_text=”Common Adverse Reactions Associated With Metoprolol | HealthGrove” ]

Percent of Reactions That Were Serious: 71%
Number of Serious Reactions: 71,979
Total Number of Reported Reactions: 100,829
Therapeutic Class: Cardiovascular Agent
Brand Names: Lopressor, Toprol Xl

44Aspirin

[graphiq id=”bltZER9qPA1″ title=”Common Adverse Reactions Associated With Aspirin” width=”600″ height=”571″ url=”https://w.graphiq.com/w/bltZER9qPA1″ link=”http://drugs.healthgrove.com/l/3072/Metoprolol” link_text=”Common Adverse Reactions Associated With Aspirin | HealthGrove” ]

Percent of Reactions That Were Serious: 71%
Number of Serious Reactions: 134,402
Total Number of Reported Reactions: 187,836
Therapeutic Class: Analgesic
Brand Names: Ascriptin, Aspergum, Aspirtab, Bayer, Easprin, Ecotrin, Ecpirin, Entercote, Genacote, Halfprin, Ninoprin, Norwich Aspirin

43Atenolol

[graphiq id=”6Liqbv86rat” title=”Common Adverse Reactions Associated With Atenolol” width=”600″ height=”571″ url=”https://w.graphiq.com/w/6Liqbv86rat” link=”http://drugs.healthgrove.com/l/3045/Atenolol” link_text=”Common Adverse Reactions Associated With Atenolol | HealthGrove” ]

Percent of Reactions That Were Serious: 72%
Number of Serious Reactions: 45,374
Total Number of Reported Reactions: 62,930
Therapeutic Class: Cardiovascular Agent
Brand Names: Tenormin

42Prednisone

[graphiq id=”1gCQMZR3RMp” title=”Common Adverse Reactions Associated With Prednisone” width=”600″ height=”571″ url=”https://w.graphiq.com/w/1gCQMZR3RMp” link=”http://drugs.healthgrove.com/l/4518/Prednisone” link_text=”Common Adverse Reactions Associated With Prednisone | HealthGrove” ]

Percent of Reactions That Were Serious: 72%
Number of Serious Reactions: 60,187
Total Number of Reported Reactions: 83,321
Therapeutic Class: Endocrine-Metabolic Agent
Brand Names: Deltasone, Prednicot, Prednisone Intensol, Rayos, Sterapred, Sterapred Ds

41Fluoxetine

[graphiq id=”36tDz6eRYuV” title=”Common Adverse Reactions Associated With Fluoxetine” width=”600″ height=”569″ url=”https://w.graphiq.com/w/36tDz6eRYuV” link=”http://drugs.healthgrove.com/l/753/Fluoxetine” link_text=”Common Adverse Reactions Associated With Fluoxetine | HealthGrove” ]

Percent of Reactions That Were Serious: 73%
Number of Serious Reactions: 36,722
Total Number of Reported Reactions: 50,213
Therapeutic Class: Antidepressant
Brand Names: Prozac, Prozac Weekly, Rapiflux, Sarafem, Selfemra, Phl-Fluoxetine

40Fentanyl

[graphiq id=”kQgrLawoElL” title=”Common Adverse Reactions Associated With Fentanyl” width=”600″ height=”571″ url=”https://w.graphiq.com/w/kQgrLawoElL” link=”http://drugs.healthgrove.com/l/734/Fentanyl” link_text=”Common Adverse Reactions Associated With Fentanyl | HealthGrove” ]

Percent of Reactions That Were Serious: 74%
Number of Serious Reactions: 29,996
Total Number of Reported Reactions: 40,444
Therapeutic Class: Analgesic
Brand Names: Abstral, Actiq, Fentora, Onsolis, Subsys

39Acetaminophen

[graphiq id=”eKywMeZvE1″ title=”Common Adverse Reactions Associated With Acetaminophen” width=”600″ height=”571″ url=”https://w.graphiq.com/w/eKywMeZvE1″ link=”http://drugs.healthgrove.com/l/4283/Acetaminophen” link_text=”Common Adverse Reactions Associated With Acetaminophen | HealthGrove” ]

Percent of Reactions That Were Serious: 74%
Number of Serious Reactions: 119,389
Total Number of Reported Reactions: 160,481
Therapeutic Class: Analgesic
Brand Names: Ofirmev

38Amlodipine

[graphiq id=”iMvReJifW4Z” title=”Common Adverse Reactions Associated With Amlodipine” width=”600″ height=”571″ url=”https://w.graphiq.com/w/iMvReJifW4Z” link=”http://drugs.healthgrove.com/l/106/Amlodipine” link_text=”Common Adverse Reactions Associated With Amlodipine | HealthGrove” ]

Percent of Reactions That Were Serious: 75%
Number of Serious Reactions: 95,694
Total Number of Reported Reactions: 126,505
Therapeutic Class: Cardiovascular Agent
Brand Names: Norvasc

37Cyclosporine

[graphiq id=”1wAVm3g4Xjv” title=”Common Adverse Reactions Associated With Cyclosporine” width=”600″ height=”571″ url=”https://w.graphiq.com/w/1wAVm3g4Xjv” link=”http://drugs.healthgrove.com/l/4721/Cyclosporine” link_text=”Common Adverse Reactions Associated With Cyclosporine | HealthGrove” ]

Percent of Reactions That Were Serious: 76%
Number of Serious Reactions: 24,422
Total Number of Reported Reactions: 31,881
Therapeutic Class: Immune Suppressant
Brand Names: Gengraf, Neoral, Sandimmune, Apo-Cyclosporine

36Risperidone

[graphiq id=”dpeAbinzxQN” title=”Common Adverse Reactions Associated With Risperidone” width=”600″ height=”571″ url=”https://w.graphiq.com/w/dpeAbinzxQN” link=”http://drugs.healthgrove.com/l/1758/Risperidone” link_text=”Common Adverse Reactions Associated With Risperidone | HealthGrove” ]

Percent of Reactions That Were Serious: 76%
Number of Serious Reactions: 34,023
Total Number of Reported Reactions: 44,415
Therapeutic Class: Antipsychotic
Brand Names: Risperdal, Risperdal M-Tab, Risperidone M-Tab

35Warfarin

[graphiq id=”iHbPInuAeTX” title=”Common Adverse Reactions Associated With Warfarin” width=”600″ height=”571″ url=”https://w.graphiq.com/w/iHbPInuAeTX” link=”http://drugs.healthgrove.com/l/3005/Warfarin” link_text=”Common Adverse Reactions Associated With Warfarin | HealthGrove” ]

Percent of Reactions That Were Serious: 76%
Number of Serious Reactions: 79,961
Total Number of Reported Reactions: 104,230
Therapeutic Class: Anticoagulant
Brand Names: Coumadin, Jantoven

34Lorazepam

[graphiq id=”fWR317R3XcV” title=”Common Adverse Reactions Associated With Lorazepam” width=”600″ height=”571″ url=”https://w.graphiq.com/w/fWR317R3XcV” link=”http://drugs.healthgrove.com/l/3495/Lorazepam” link_text=”Common Adverse Reactions Associated With Lorazepam | HealthGrove” ]

Percent of Reactions That Were Serious: 77%
Number of Serious Reactions: 42,737
Total Number of Reported Reactions: 54,873
Therapeutic Class: Antianxiety
Brand Names: Ativan, Lorazepam Intensol

33Valsartan

[graphiq id=”hk1rmKFP63r” title=”Common Adverse Reactions Associated With Valsartan” width=”600″ height=”571″ url=”https://w.graphiq.com/w/hk1rmKFP63r” link=”http://drugs.healthgrove.com/l/1810/Diovan” link_text=”Common Adverse Reactions Associated With Valsartan | HealthGrove” ]

Percent of Reactions That Were Serious: 77%
Number of Serious Reactions: 46,987
Total Number of Reported Reactions: 60,639
Therapeutic Class: Cardiovascular Agent
Brand Names: Diovan

32Pantoprazole

[graphiq id=”bPlRYfoMwFn” title=”Common Adverse Reactions Associated With Pantoprazole” width=”600″ height=”571″ url=”https://w.graphiq.com/w/bPlRYfoMwFn” link=”http://drugs.healthgrove.com/l/3178/Pantoprazole” link_text=”Common Adverse Reactions Associated With Pantoprazole | HealthGrove” ]

Percent of Reactions That Were Serious: 77%
Number of Serious Reactions: 48,736
Total Number of Reported Reactions: 62,968
Therapeutic Class: Gastric Acid Secretion Inhibitor
Brand Names: Protonix, Protonix Iv

31Oxycodone

[graphiq id=”3AlvSuudFAh” title=”Common Adverse Reactions Associated With Oxycodone” width=”600″ height=”571″ url=”https://w.graphiq.com/w/3AlvSuudFAh” link=”http://drugs.healthgrove.com/l/4113/Oxycodone” link_text=”Common Adverse Reactions Associated With Oxycodone | HealthGrove” ]

Percent of Reactions That Were Serious: 77%
Number of Serious Reactions: 56,165
Total Number of Reported Reactions: 72,020
Therapeutic Class: Analgesic
Brand Names: Dazidox, Eth-Oxydose, Oxaydo, Oxycontin, Oxycontin Cr, Oxydose, Oxyfast, Oxy Ir, Roxicodone, Roxicodone Intensol, Apo-Oxycodone Cr, Co Oxycodone Cr, Oxycodone, Oxy-Ir, Oxyneo, Pms-Oxycodone

30Drospirenone And Ethinyl Estradiol

[graphiq id=”hwJLeaPQYol” title=”Common Adverse Reactions Associated With Drospirenone And Ethinyl Estradiol” width=”600″ height=”571″ url=”https://w.graphiq.com/w/hwJLeaPQYol” link=”http://drugs.healthgrove.com/l/145/Drospirenone-And-Ethinyl-Estradiol” link_text=”Common Adverse Reactions Associated With Drospirenone And Ethinyl Estradiol | HealthGrove” ]

Percent of Reactions That Were Serious: 78%
Number of Serious Reactions: 31,921
Total Number of Reported Reactions: 40,426
Therapeutic Class: Monophasic Contraceptive Combination
Brand Names: Gianvi, Loryna, Nikki, Ocella, Syeda, Vestura, Yasmin, Yaz, Yaz 28, Zarah

29Citalopram

[graphiq id=”6a2fx2woyVf” title=”Common Adverse Reactions Associated With Citalopram” width=”600″ height=”571″ url=”https://w.graphiq.com/w/6a2fx2woyVf” link=”http://drugs.healthgrove.com/l/457/Citalopram” link_text=”Common Adverse Reactions Associated With Citalopram | HealthGrove” ]

Percent of Reactions That Were Serious: 78%
Number of Serious Reactions: 42,147
Total Number of Reported Reactions: 53,752
Therapeutic Class: Antidepressant
Brand Names: Celexa

28Diclofenac

[graphiq id=”bEHOVxNr8jj” title=”Common Adverse Reactions Associated With Diclofenac” width=”600″ height=”571″ url=”https://w.graphiq.com/w/bEHOVxNr8jj” link=”http://drugs.healthgrove.com/l/2598/Diclofenac” link_text=”Common Adverse Reactions Associated With Diclofenac | HealthGrove” ]

Percent of Reactions That Were Serious: 79%
Number of Serious Reactions: 27,921
Total Number of Reported Reactions: 35,286
Therapeutic Class: Central Nervous System Agent
Brand Names: Cambia, Cataflam, Voltaren, Voltaren-Xr, Zipsor, Zorvolex

27Conjugated Estrogens

[graphiq id=”jTIb1iHZZop” title=”Common Adverse Reactions Associated With Conjugated Estrogens” width=”600″ height=”601″ url=”https://w.graphiq.com/w/jTIb1iHZZop” link=”http://drugs.healthgrove.com/l/4552/Premarin” link_text=”Common Adverse Reactions Associated With Conjugated Estrogens | HealthGrove” ]

Percent of Reactions That Were Serious: 79%
Number of Serious Reactions: 40,659
Total Number of Reported Reactions: 51,272
Therapeutic Class: Female Reproductive Agent
Brand Names: Premarin, Premarin Vaginal

26Olanzapine

[graphiq id=”kh4xVqtng5n” title=”Common Adverse Reactions Associated With Olanzapine” width=”600″ height=”571″ url=”https://w.graphiq.com/w/kh4xVqtng5n” link=”http://drugs.healthgrove.com/l/3150/Olanzapine” link_text=”Common Adverse Reactions Associated With Olanzapine | HealthGrove” ]

Percent of Reactions That Were Serious: 80%
Number of Serious Reactions: 32,222
Total Number of Reported Reactions: 39,957
Therapeutic Class: Antipsychotic
Brand Names: Zyprexa, Zyprexa Zydis

25Diazepam

[graphiq id=”lXsLxJW8HFb” title=”Common Adverse Reactions Associated With Diazepam” width=”600″ height=”571″ url=”https://w.graphiq.com/w/lXsLxJW8HFb” link=”http://drugs.healthgrove.com/l/3509/Diazepam” link_text=”Common Adverse Reactions Associated With Diazepam | HealthGrove” ]

Percent of Reactions That Were Serious: 81%
Number of Serious Reactions: 31,794
Total Number of Reported Reactions: 38,978
Therapeutic Class: Anticonvulsant
Brand Names: Diastat, Diastat Pediatric

24Rivaroxaban

[graphiq id=”6QCrHQVM8lv” title=”Common Adverse Reactions Associated With Rivaroxaban” width=”600″ height=”571″ url=”https://w.graphiq.com/w/6QCrHQVM8lv” link=”http://drugs.healthgrove.com/l/4411/Xarelto” link_text=”Common Adverse Reactions Associated With Rivaroxaban | HealthGrove” ]

Percent of Reactions That Were Serious: 81%
Number of Serious Reactions: 33,317
Total Number of Reported Reactions: 41,114
Therapeutic Class: Anticoagulant
Brand Names: Xarelto

23Alendronate

[graphiq id=”1HeYoKRqlFz” title=”Common Adverse Reactions Associated With Alendronate” width=”600″ height=”571″ url=”https://w.graphiq.com/w/1HeYoKRqlFz” link=”http://drugs.healthgrove.com/l/42/Alendronate” link_text=”Common Adverse Reactions Associated With Alendronate | HealthGrove” ]

Percent of Reactions That Were Serious: 82%
Number of Serious Reactions: 39,257
Total Number of Reported Reactions: 47,769
Therapeutic Class: Calcium Regulator
Brand Names: Fosamax

22Clopidogrel

[graphiq id=”fqUTT131M8J” title=”Common Adverse Reactions Associated With Clopidogrel” width=”600″ height=”571″ url=”https://w.graphiq.com/w/fqUTT131M8J” link=”http://drugs.healthgrove.com/l/515/Clopidogrel” link_text=”Common Adverse Reactions Associated With Clopidogrel | HealthGrove” ]

Percent of Reactions That Were Serious: 82%
Number of Serious Reactions: 70,205
Total Number of Reported Reactions: 85,447
Therapeutic Class: Platelet Aggregation Inhibitor
Brand Names: Plavix

21Furosemide

[graphiq id=”bjpIQ8AKlBb” title=”Common Adverse Reactions Associated With Furosemide” width=”600″ height=”571″ url=”https://w.graphiq.com/w/bjpIQ8AKlBb” link=”http://drugs.healthgrove.com/l/3125/Furosemide” link_text=”Common Adverse Reactions Associated With Furosemide | HealthGrove” ]

Percent of Reactions That Were Serious: 82%
Number of Serious Reactions: 102,865
Total Number of Reported Reactions: 124,020
Therapeutic Class: Cardiovascular Agent
Brand Names: Furocot, Lasix

20Digoxin

[graphiq id=”jyq4VTvjcGh” title=”Common Adverse Reactions Associated With Digoxin” width=”600″ height=”571″ url=”https://w.graphiq.com/w/jyq4VTvjcGh” link=”http://drugs.healthgrove.com/l/3607/Digoxin” link_text=”Common Adverse Reactions Associated With Digoxin | HealthGrove” ]

Percent of Reactions That Were Serious: 83%
Number of Serious Reactions: 30,355
Total Number of Reported Reactions: 36,506
Therapeutic Class: Cardiovascular Agent
Brand Names: Digitek, Digox, Lanoxicaps, Lanoxin, Lanoxin Pediatric, Digitaline Nativelle

19Spironolactone

[graphiq id=”2nPazzgNV5P” title=”Common Adverse Reactions Associated With Spironolactone” width=”600″ height=”571″ url=”https://w.graphiq.com/w/2nPazzgNV5P” link=”http://drugs.healthgrove.com/l/3219/Spironolactone” link_text=”Common Adverse Reactions Associated With Spironolactone | HealthGrove” ]

Percent of Reactions That Were Serious: 84%
Number of Serious Reactions: 28,871
Total Number of Reported Reactions: 34,336
Therapeutic Class: Cardiovascular Agent
Brand Names: Aldactone

18Allopurinol

[graphiq id=”g7v63PsplyZ” title=”Common Adverse Reactions Associated With Allopurinol” width=”600″ height=”571″ url=”https://w.graphiq.com/w/g7v63PsplyZ” link=”http://drugs.healthgrove.com/l/4610/Allopurinol” link_text=”Common Adverse Reactions Associated With Allopurinol | HealthGrove” ]

Percent of Reactions That Were Serious: 84%
Number of Serious Reactions: 30,921
Total Number of Reported Reactions: 36,755
Therapeutic Class: Antigout
Brand Names: Aloprim

17Morphine

[graphiq id=”bZZV0X07V1r” title=”Common Adverse Reactions Associated With Morphine” width=”600″ height=”571″ url=”https://w.graphiq.com/w/bZZV0X07V1r” link=”http://drugs.healthgrove.com/l/4128/Morphine” link_text=”Common Adverse Reactions Associated With Morphine | HealthGrove” ]

Percent of Reactions That Were Serious: 84%
Number of Serious Reactions: 37,986
Total Number of Reported Reactions: 44,906
Therapeutic Class: Analgesic
Brand Names: Avinza, Kadian, Kadian Er, Morphabond, Ms Contin, Msir, Oramorph Sr, Roxanol, Roxanol-T

16Ondansetron

[graphiq id=”idUHlrAnUqh” title=”Common Adverse Reactions Associated With Ondansetron” width=”600″ height=”571″ url=”https://w.graphiq.com/w/idUHlrAnUqh” link=”http://drugs.healthgrove.com/l/1159/Ondansetron” link_text=”Common Adverse Reactions Associated With Ondansetron | HealthGrove” ]

Percent of Reactions That Were Serious: 85%
Number of Serious Reactions: 31,005
Total Number of Reported Reactions: 36,133
Therapeutic Class: Antiemetic
Brand Names: Zofran, Zofran Odt, Zuplenz

15Ramipril

[graphiq id=”1JTZ9VLgcg5″ title=”Common Adverse Reactions Associated With Ramipril” width=”600″ height=”571″ url=”https://w.graphiq.com/w/1JTZ9VLgcg5″ link=”http://drugs.healthgrove.com/l/2370/Ramipril” link_text=”Common Adverse Reactions Associated With Ramipril | HealthGrove” ]

Percent of Reactions That Were Serious: 85%
Number of Serious Reactions: 32,374
Total Number of Reported Reactions: 37,895
Therapeutic Class: Antihypertensive
Brand Names: Altace

14Rosiglitazone

[graphiq id=”bm4JBjuAcbH” title=”Common Adverse Reactions Associated With Rosiglitazone” width=”600″ height=”571″ url=”https://w.graphiq.com/w/bm4JBjuAcbH” link=”http://drugs.healthgrove.com/l/1680/Avandia” link_text=”Common Adverse Reactions Associated With Rosiglitazone | HealthGrove” ]

Percent of Reactions That Were Serious: 85%
Number of Serious Reactions: 87,352
Total Number of Reported Reactions: 101,873
Therapeutic Class: Antidiabetic
Brand Names: Avandia

13Medroxyprogesterone

[graphiq id=”QKMroEU5L” title=”Common Adverse Reactions Associated With Medroxyprogesterone” width=”600″ height=”571″ url=”https://w.graphiq.com/w/QKMroEU5L” link=”http://drugs.healthgrove.com/l/16031/Medroxyprogesterone” link_text=”Common Adverse Reactions Associated With Medroxyprogesterone | HealthGrove” ]

Percent of Reactions That Were Serious: 89%
Number of Serious Reactions: 34,018
Total Number of Reported Reactions: 38,079
Therapeutic Class: Endocrine-Metabolic Agent
Brand Names: Provera, Alti-Mpa

12Lenalidomide

[graphiq id=”iUuTwfZLtQx” title=”Common Adverse Reactions Associated With Lenalidomide” width=”600″ height=”571″ url=”https://w.graphiq.com/w/iUuTwfZLtQx” link=”http://drugs.healthgrove.com/l/2165/Revlimid” link_text=”Common Adverse Reactions Associated With Lenalidomide | HealthGrove” ]

Percent of Reactions That Were Serious: 89%
Number of Serious Reactions: 69,123
Total Number of Reported Reactions: 77,417
Therapeutic Class: Immune Modulator
Brand Names: Revlimid

11Methylprednisolone

[graphiq id=”aFuxqv5cCLr” title=”Common Adverse Reactions Associated With Methylprednisolone” width=”600″ height=”601″ url=”https://w.graphiq.com/w/aFuxqv5cCLr” link=”http://drugs.healthgrove.com/l/4507/Methylprednisolone” link_text=”Common Adverse Reactions Associated With Methylprednisolone | HealthGrove” ]

Percent of Reactions That Were Serious: 90%
Number of Serious Reactions: 30,040
Total Number of Reported Reactions: 33,095
Therapeutic Class: Endocrine-Metabolic Agent
Brand Names: Medrol, Medrol Dosepak, Methylpred-Dp

10Metoclopramide

[graphiq id=”13jMZ7lSCPP” title=”Common Adverse Reactions Associated With Metoclopramide” width=”600″ height=”601″ url=”https://w.graphiq.com/w/13jMZ7lSCPP” link=”http://drugs.healthgrove.com/l/1037/Metoclopramide” link_text=”Common Adverse Reactions Associated With Metoclopramide | HealthGrove” ]

Percent of Reactions That Were Serious: 91%
Number of Serious Reactions: 32,757
Total Number of Reported Reactions: 35,623
Therapeutic Class: Antiemetic
Brand Names: Metozolv Odt, Reglan

9Infliximab

[graphiq id=”3NEzGmZoUwR” title=”Common Adverse Reactions Associated With Infliximab” width=”600″ height=”571″ url=”https://w.graphiq.com/w/3NEzGmZoUwR” link=”http://drugs.healthgrove.com/l/2175/Remicade” link_text=”Common Adverse Reactions Associated With Infliximab | HealthGrove” ]

Percent of Reactions That Were Serious: 91%
Number of Serious Reactions: 68,167
Total Number of Reported Reactions: 74,738
Therapeutic Class: Immunological Agent
Brand Names: Remicade

8Tacrolimus

[graphiq id=”1oBT4wyzpxX” title=”Common Adverse Reactions Associated With Tacrolimus” width=”600″ height=”571″ url=”https://w.graphiq.com/w/1oBT4wyzpxX” link=”http://drugs.healthgrove.com/l/2149/Tacrolimus” link_text=”Common Adverse Reactions Associated With Tacrolimus | HealthGrove” ]

Percent of Reactions That Were Serious: 92%
Number of Serious Reactions: 27,964
Total Number of Reported Reactions: 30,262
Therapeutic Class: Antipsoriatic
Brand Names: Protopic

7Zoledronic Acid

[graphiq id=”9DCfaht8gD3″ title=”Common Adverse Reactions Associated With Zoledronic Acid” width=”600″ height=”571″ url=”https://w.graphiq.com/w/9DCfaht8gD3″ link=”http://drugs.healthgrove.com/l/1675/Reclast” link_text=”Common Adverse Reactions Associated With Zoledronic Acid | HealthGrove” ]

Percent of Reactions That Were Serious: 93%
Number of Serious Reactions: 35,581
Total Number of Reported Reactions: 38,016
Therapeutic Class: Calcium Regulator
Brand Names: Reclast, Zometa

6Dexamethasone

[graphiq id=”gvscUpyVYRD” title=”Common Adverse Reactions Associated With Dexamethasone” width=”600″ height=”601″ url=”https://w.graphiq.com/w/gvscUpyVYRD” link=”http://drugs.healthgrove.com/l/4488/Dexamethasone” link_text=”Common Adverse Reactions Associated With Dexamethasone | HealthGrove” ]

Percent of Reactions That Were Serious: 93%
Number of Serious Reactions: 38,966
Total Number of Reported Reactions: 41,636
Therapeutic Class: Endocrine-Metabolic Agent
Brand Names: Baycadron Elixer, Decadron, Dekpak 13 Day Taperpak, Dexamethasone Intensol, Dexpak, Dexpak 10 Day Taperpak, Dexpak Jr, Zema-Pak

5Clozapine

[graphiq id=”7zREDQeZymh” title=”Common Adverse Reactions Associated With Clozapine” width=”600″ height=”571″ url=”https://w.graphiq.com/w/7zREDQeZymh” link=”http://drugs.healthgrove.com/l/1641/Clozapine” link_text=”Common Adverse Reactions Associated With Clozapine | HealthGrove” ]

Percent of Reactions That Were Serious: 95%
Number of Serious Reactions: 29,470
Total Number of Reported Reactions: 30,914
Therapeutic Class: Antipsychotic
Brand Names: Clozaril, Fazaclo, Versacloz

4Rituximab

[graphiq id=”25c5fkXWYYd” title=”Common Adverse Reactions Associated With Rituximab” width=”600″ height=”571″ url=”https://w.graphiq.com/w/25c5fkXWYYd” link=”http://drugs.healthgrove.com/l/2051/Rituximab” link_text=”Common Adverse Reactions Associated With Rituximab | HealthGrove” ]

Percent of Reactions That Were Serious: 96%
Number of Serious Reactions: 30,014
Total Number of Reported Reactions: 31,157
Therapeutic Class: Antineoplastic Agent
Brand Names: Rituxan

3Bevacizumab

[graphiq id=”ljxA86qAYPr” title=”Common Adverse Reactions Associated With Bevacizumab” width=”600″ height=”571″ url=”https://w.graphiq.com/w/ljxA86qAYPr” link=”http://drugs.healthgrove.com/l/2171/Avastin” link_text=”Common Adverse Reactions Associated With Bevacizumab | HealthGrove” ]

Percent of Reactions That Were Serious: 96%
Number of Serious Reactions: 39,957
Total Number of Reported Reactions: 41,281
Therapeutic Class: Immunological Agent
Brand Names: Avastin

2Prednisolone

[graphiq id=”hc2p5dYjyhT” title=”Common Adverse Reactions Associated With Prednisolone” width=”600″ height=”571″ url=”https://w.graphiq.com/w/hc2p5dYjyhT” link=”http://drugs.healthgrove.com/l/4476/Prednisolone” link_text=”Common Adverse Reactions Associated With Prednisolone | HealthGrove” ]

Percent of Reactions That Were Serious: 96%
Number of Serious Reactions: 42,323
Total Number of Reported Reactions: 43,817
Therapeutic Class: Endocrine-Metabolic Agent
Brand Names: Bubbli-Pred, Cotolone, Flo-Pred, Millipred, Millipred Dp, Orapred, Orapred Odt, Pediapred, Prelone, Veripred 20, Pms-Prednisolone

1Cyclophosphamide

[graphiq id=”8X22Zt3KHcN” title=”Common Adverse Reactions Associated With Cyclophosphamide” width=”600″ height=”601″ url=”https://w.graphiq.com/w/8X22Zt3KHcN” link=”http://drugs.healthgrove.com/l/555/Cyclophosphamide” link_text=”Common Adverse Reactions Associated With Cyclophosphamide | HealthGrove” ]

Percent of Reactions That Were Serious: 97%
Number of Serious Reactions: 33,128
Total Number of Reported Reactions: 34,076
Therapeutic Class: Antineoplastic Agent
Brand Names: Cytoxan, Cytoxan Lyophilized

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